Bioregulator Peptides.
Forty years of evidence.
Bioregulator peptides are short-chain amino acid sequences — two to seven amino acids — that occur naturally in the human body and decline with age. Vladimir Khavinson's institute has produced over 800 peer-reviewed publications on these compounds since the 1970s.
The Tissue Architect
A naturally occurring tripeptide found in human plasma. Levels decline from ~200 ng/ml at age 20 to ~80 ng/ml by age 60 — following the same timeline as visible tissue changes. Published research documents GHK's role in collagen synthesis, gene expression modulation across 4,000+ human genes, and longevity signaling pathways. The non-copper form used in HelioMend formulas is distinct from GHK-Cu.
Pickart et al., Int J Mol Sci 2018 · Abdulghani et al., comparative collagen trial 1999
The Vascular Signal
A vascular endothelial bioregulator with published research on connexin gap junction restoration, endothelin normalization, and SIRT1 upregulation in aging vascular cells. Acts synergistically with GHK to support nitric oxide availability and endothelial function.
Khavinson Institute vascular bioregulator series · eNOS pathway and KED co-administration research
The Longevity Signal
Published research documents telomerase activation via hTERT upregulation, pineal gland bioregulation, and epigenetic clock modulation. A peer-reviewed study from Brunel University London (2025) confirmed hTERT upregulation. Long-term human clinical data shows significant reduction in all-cause mortality over six years.
PMC12411320 (hTERT, Brunel 2025) · Khavinson longevity cohort studies · Anisimov et al.
Why Transdermal Delivery Works
The 500 Dalton Rule
Passive transdermal penetration is governed by molecular size. Compounds below 500 Daltons can penetrate intact skin. GHK (340 Da), KED (390 Da), AEDG (432 Da) — all three bioregulators pass this threshold. Ethoxydiglycol (Transcutol) in HelioMend formulas provides an estimated 60% improvement over unaided delivery.
Intramuscular Delivery Confirmed
LactiGo's University of Montana human biopsy confirmed intramuscular delivery of transdermal peptides within 60 minutes using the same delivery class. Published PLGA nanoparticle research on GHK confirms 94% entrapment efficiency and 90% release within 48 hours.