AEDG: Telomerase Activation and the Longevity Signal
AEDG is a tetrapeptide bioregulator with published research documenting hTERT upregulation, pineal gland bioregulation, epigenetic clock modulation, and significant reduction in all-cause mortality across multi-year human cohort studies. A 2025 peer-reviewed study from Brunel University London confirmed hTERT upregulation in human cells.
Telomerase upregulation
A 2025 peer-reviewed study from Brunel University London documented hTERT upregulation following AEDG exposure. Telomerase activity is a primary mechanism for telomere maintenance and is associated with cellular replicative capacity.
Pineal gland bioregulation
AEDG (also known as Epitalon) was originally developed as a pineal gland bioregulator with effects on melatonin synthesis and circadian regulation. The compound's pineal-modulating activity is documented across multiple Khavinson Institute publications.
Mortality reduction in cohort data
Long-term human cohort studies from the Khavinson Institute documented significant reductions in all-cause mortality over six-year follow-up periods in elderly populations receiving AEDG. The cohort design and outcomes are detailed in Anisimov and Khavinson's biogerontology reviews.
Molecular weight and delivery
At 432 Daltons, AEDG falls below the 500 Dalton threshold for passive transdermal penetration. The compound is the third bioregulator active in HelioMend formulations alongside GHK and KED.
Citations
- Brunel University London. AEDG and hTERT upregulation in human cells. 2025. [link]
- Anisimov VN, Khavinson VKh. Peptide bioregulation of aging: results and prospects. Biogerontology. 2010;11(2):139-49.
- Khavinson VKh et al. Long-term peptide bioregulator cohort studies. St. Petersburg Institute of Bioregulation and Gerontology.